Fungicidal combinations

ABSTRACT

A combination including a dithiocarbamate fungicide, a succinate dehydrogenase fungicide and at least one of ergosterol biosynthesis inhibitor fungicide or a quinone outside inhibitor fungicide.

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a Continuation of U.S. application Ser. No.17/130,193,

filed on Dec. 22, 2020, which is a Continuation of U.S. ApplicationSerial No.

16/347,283, filed on May 3, 2019, which is a National Stage applicationof

PCT/M2017/056710, filed on Oct. 30, 2017, which claims the benefit of Indian

Application No. 201631037704, filed on Nov. 4, 2016, both of which areincorporated

by reference in their entirety herein.

TECHNICAL FIELD

The present invention relates to a combination of fungicides. Morespecifically, the present invention relates to fungicidal combinationscomprising succinate dehydrogenase inhibitor fungicides for controllinga broad spectrum of fungal diseases.

BACKGROUND OF THE INVENTION

Fungicides are an integral and important tool yielded by farmers tocontrol diseases, as well as to improve yields and quality of the crops.There are various fungicides that have been developed over the yearswith many desirable attributes such as specificity, systemicity,curative and eradicant action and high activity at low use rates.

Succinate dehydrogenase inhibitor (SDHI) fungicides are known in the artto be broad spectrum and have a high potency. Pyrazolecarboxamides are agroup of active compounds within the SDHI family of fungicides that areknown to be more potent than most other SDHI fungicides. These moleculesspecifically bind to the ubiquinone-binding site (Q-site) of themitochondrial complex II, thereby inhibiting fungal respiration. Thesefungicides are known to control a broad spectrum of fungal diseases.

Various other classes of fungicides are also known in the art, such asQuinone outside inhibitors (QoIs), ergosterol-biosynthesis inhibitors,fungicides that act on multiple sites, fungicides that affect mitosisetc. These fungicides have been mixed with SDHI fungicides to achieve abroad spectrum of disease control.

WO2006037632 teaches combinations of SDHI fungicides with a secondactive compound. WO2013127818 teaches combinations of SDHI fungicideswith various herbicides. WO2006037634 teaches methods of controllingfungi using a combination of SDHI fungicide with various fungicides.However, the prior art does not teach the use of ternary or highercombinations of SDHI fungicides.

Dithiocarbamate are known in the art as multi-site fungicides. Thesefungicides are used for broad-spectrum disease control in more than 70crops. Mancozeb is especially important for controlling devastating andfast spreading diseases such as Phytophthora infestans, Venturiainaequalis etc. Dithiocarbamate fungicides, especially mancozeb, areparticularly useful for disease control because of their broad spectrumof activity, high tolerance by crop plants, and general usefulness forcontrolling fungal plant diseases not controlled by active compoundsthat act on only a single target site in the fungus.

Mancozeb has been combined with various SDHI fungicides for diseasecontrol. There is a need in the art to improve on the disease spectrumprovided by these combinations.

There is therefore a need in the art for combinations of SDHIs with aspecific fungicide that helps improve spectrum. With crop tolerancesdecreasing, lower use rates being imposed and resistance beingincreasingly observed, there is a need for a combination of actives thatallows for broader disease control spectrum that combines curative andpreventive actives and has a lower dosage.

Therefore, embodiments of the present invention may ameliorate one ormore of the above mentioned problems.

Therefore, embodiments of the present invention may provide combinationsof fungicides that possess an enhanced efficacy over the individualfungicides used in isolation.

Another object of the present invention is to provide a fungicidalcombination that causes an enhanced greening of the crops to which it isadministered.

Another object of the present invention is to provide a fungicidalcombination that causes late senescence to the crop to which it isapplied thereby resulting into an increasing yield of the crop.

Yet another object of the present invention is to provide a fungicidalcombination that results into reduced fungal disease incidence in thecrops to which it is applied.

Another object of the present invention is to provide a fungicidalcombination that achieves increased yield in the crops to which it isapplied.

Some or all these and other objects of the invention are can be achievedby way of the invention described hereinafter.

SUMMARY OF THE INVENTION

Thus, an aspect of the present invention can provide a fungicidalcombination comprising at least one succinate dehydrogenase inhibitorfungicide, at least one dithiocarbamate fungicide, and at least anotherfungicide.

Another aspect of the present invention can provide a fungicidalcombination comprising at least one succinate dehydrogenase inhibitorfungicide, at least one dithiocarbamate fungicide and at least two otherfungicides.

Another aspect of the present invention can provide synergisticcompositions comprising at least one succinate dehydrogenase inhibitorfungicide, at least one dithiocarbamate fungicide, and at least oneother fungicide.

Another aspect of the present invention can provide synergisticcompositions comprising at least one succinate dehydrogenase inhibitorfungicide, at least one dithiocarbamate fungicide and at least two otherfungicides.

DETAILED DESCRIPTION

The term ‘disease control’ as used herein denotes control and preventionof a disease. Controlling effects include all deviation from naturaldevelopment, for example: killing, retardation, decrease of the fugaldisease. The term ‘plants’ refers to all physical parts of a plant,including seeds, seedlings, saplings, roots, tubers, stems, stalks,foliage and fruits. The term “locus” of a plant as used herein isintended to embrace the place on which the plants are growing, where theplant propagation materials of the plants are sown or where the plantpropagation materials of the plants will be placed into the soil. Theterm “plant propagation material” is understood to denote generativeparts of a plant, such as seeds, vegetative material such as cuttings ortubers, roots, fruits, tubers, bulbs, rhizomes and parts of plants,germinated plants and young plants which are to be transplanted aftergermination or after emergence from the soil. These young plants may beprotected before transplantation by a total or partial treatment byimmersion. The term “agriculturally acceptable amount of active” refersto an amount of an active that kills or inhibits the plant disease forwhich control is desired, in an amount not significantly toxic to theplant being treated.

Succinate dehydrogenase inhibitor (SDHI) fungicides play an importantrole in plant protection against many phytopathogenic fungi. Thesemolecules specifically bind to the ubiquinone-binding site (Q-site) ofthe mitochondrial complex II, thereby inhibiting fungal respiration.Dithiocarbamate are multi-site contact fungicides. These moleculesattack multiple sites within the fugal cells.

It has surprisingly been found that the addition of a dithiocarbamatefungicide to the combinations of succinate dehydrogenase inhibitors withat least another fungicide selected from an ergosterol biosynthesisinhibitors or Quinone outside inhibitors or a combination thereof,resulted in surprising and unexpected advantages. It was surprising thatthe addition of a dithiocarbamate fungicide to the combination of asuccinate dehydrogenase inhibitor with at least another fungicideselected from an ergosterol biosynthesis inhibitors and/or Quinoneoutside inhibitors or a combination thereof resulted in an enhancementof the efficacy, and a surprising reduction in fungal disease incidence,seen only with the combination of succinate dehydrogenase inhibitorswith at least another fungicide selected from an ergosterol biosynthesisinhibitors or Quinone outside inhibitors or a combination thereof. Ithas further been found that the addition of a dithiocarbamate fungicideto these combinations and application of these combinations during theflowering stage of the crop delayed the senescence in the crop to whichthey were applied, which led to better greening in the crop therebyincreasing the level of photosynthesis occurring within the plant,thereby leading to a greater yield from the crop to which they wereapplied.

These surprising advantages of the combinations of the invention werenot observed when the dithiocarbamate fungicide was not present in thecombination. Therefore, these unexpected advantages of the combinationof the present invention could be attributed to the inclusion of adithiocarbamate fungicide to the combination of a succinatedehydrogenase inhibitor with at least another fungicide selected from anergosterol biosynthesis inhibitors and/or Quinone outside inhibitors ora combination thereof.

Thus, in an aspect, the present invention provides a fungicidalcombination comprising:

(a) at least one dithiocarbamate fungicide;

(b) at least one succinate dehydrogenase inhibitor fungicide; and

(c) at least another fungicide selected from an ergosterol biosynthesisinhibitors and/or

Quinone outside inhibitors.

In an embodiment, the dithiocarbamate fungicide is selected from thegroup consisting of amobam, asomate, azithiram, carbamorph, cufraneb,cuprobam, disulfiram, ferbam, metam, nabam, tecoram, thiram, urbacide,ziram, dazomet, etem, milneb, mancopper, mancozeb, maneb, metiram,polycarbamate, propineb and zineb.

In an embodiment, the preferred dithiocarbamate fungicide is mancozeb.

In an embodiment, the succinate dehydrogenase inhibitor is selected frompyrazole carboxamide class of succinate dehydrogenase inhibitorfungicides. However, it should be understood that the choice ofsuccinate dehydrogenase inhibitors is not understood to be limited tothese pyrazole carboxamide fungicides alone.

In an embodiment, the pyrazole carboxamide class of succinatedehydrogenase inhibitor fungicide may be selected from benzovindiflupyr,bixafen, fluxapyroxad, furametpyr, isopyrazam, penflufen, penthiopyrad,and sedaxane.

Benzovindiflupyr has the chemical nameN-R1RS,4SR)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methylpyrazole-4-carboxamideand has the structure:

Bixafen has the chemical nameN-(3′,4′-dichloro-5-fluorobiphenyl-2-yl)-3-(difluoromethyl)-1-methylpyrazole-4-carboxamideand the structure:

Fluxapyroxad has the chemical name3-(difluoromethyl)-1-methyl-N-(3′,4′,5′-trifluorobiphenyl-2-yl)pyrazole-4-carboxamideand has the structure:

Furametpyr has the chemical name(RS)-5-chloro-N-(1,3-dihydro-1,1,3-trimethylisobenzofuran-4-yl)-1,3-dimethylpyrazole-4-carboxamideand has the structure:

Isopyrazam is a mixture of 2 isomers3-(difluoromethyl)-1-methyl-N-[(1RS,4SR,9RS)-1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-yl]pyrazole-4-carboxamideand 2 aisomers3-(difluoromethyl)-1-methyl-N-[(1RS,4SR,9SR)-1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-yl]pyrazole-4-carboxamide and its tautomer's have the structure:

Penflufen has the chemical nameN-[2-(1,3-dimethylbutyl)phenyl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide,and has the following structure:

Penthiopyrad has the chemical name(RS)-N-[2-(1,3-dimethylbutyl)-3-thienyl]-1-methyl-3-(trifluoromethyl)pyrazole-4-carboxamide,and has the following structure:

Sedaxane is a mixture of 2 cis-isomers2′-[(1RS,2RS)-1,1′-bicycloprop-2-yl]-3-(difluoromethyl)-1-methylpyrazole-4-carboxanilideand 2 trans-isomers 2′-[(1RS,2SR)-1,1′-bicycloprop-2-yl]-3-(difluoromethyl)-1-methylpyrazole-4-carboxanilide, and itstautomer's have the structure:

In an embodiment, the succinate dehydrogenase inhibitor fungicide may beselected from the group consisting of benodanil, flutolanil, mepronil,isofetamid, fluopyram, fenfuram, carboxin, oxycarboxin, thifluzamide,boscalid and IR9792.

In an embodiment, the third and/or fourth fungicides in the combinationsof the present invention may be selected from ergosterol biosynthesisinhibitors, and/or Quinone outside (Qo) inhibitors or mixtures thereof.

Thus in an embodiment, the ergosterol biosynthesis inhibitors may beselected from the group consisting of azaconazole, bitertanol,bromuconazole, cyproconazole, difenoconazole, diniconazole,epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole,flutriafol, hexaconazole, imibenconazole, Ipconazole, metconazole,myclobutanil, penconazole, Propiconazole, simeconazole, tebuconazole,tetraconazole, triadimefon, triadimenol, triticonazole, prothioconazole,imazalil, oxpoconazole, pefurazoate, prochloraz, triflumizole,fenarimol, nuarimol, pyrifenox, pyrisoxazole, triforine and mixturesthereof.

In another embodiment, the ergosterol biosynthesis inhibitors may beselected from prothioconazole, tebuconazole, hexaconazole, cyroconazoleor epoxiconazole.

In an embodiment, the third fungicide may be a Quinone outside (Qo)inhibitor fungicide selected from azoxystrobin, coumoxystrobin,enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin,mandestrobin, pyraclostrobin, pyrametostrobin, triclopyricarb,kresoxim-methyl, dimoxystrobin, fenaminostrobin, metominostrobin,trifloxystrobin, famoxadone, fluoxastrobin, fenamidone, pyribencarb andmixtures thereof.

In an embodiment, the Quinone outside (Qo) inhibitor fungicide may beselected from azoxystrobin, picoxystrobin, kresoxim-methyl,pyraclostrobin and trifloxystrobin.

In an embodiment of the combinations of the present invention, thepreferred succinate dehydrogenase inhibitor fungicide is isopyrazam.

In an embodiment, the combinations of the present invention include thefollowing preferred combinations:

S No. I II III IV 1 Mancozeb Isopyrazam Cyproconazole — 2 MancozebIsopyrazam Difenoconazole — 3 Mancozeb Isopyrazam Epoxiconazole — 4Mancozeb Isopyrazam Hexaconazole — 5 Mancozeb Isopyrazam Tebuconazole —6 Mancozeb Isopyrazam Tetraconazole — 7 Mancozeb IsopyrazamProthioconazole — 8 Mancozeb Isopyrazam — Azoxystrobin 9 MancozebIsopyrazam — Picoxystrobin 10 Mancozeb Isopyrazam — Pyraclostrobin 11Mancozeb Isopyrazam — Kresoxim- methyl 12 Mancozeb Isopyrazam —Trifloxystrobin 13 Mancozeb Isopyrazam Cyproconazole Azoxystrobin 14Mancozeb Isopyrazam Cyproconazole Picoxystrobin 15 Mancozeb IsopyrazamCyproconazole Pyraclostrobin 16 Mancozeb Isopyrazam CyproconazoleKresoxim- methyl 17 Mancozeb Isopyrazam Cyproconazole Trifloxystrobin 18Mancozeb Isopyrazam Difenoconazole Azoxystrobin 19 Mancozeb IsopyrazamDifenoconazole Picoxystrobin 20 Mancozeb Isopyrazam DifenoconazolePyraclostrobin 21 Mancozeb Isopyrazam Difenoconazole Kresoxim- methyl 22Mancozeb Isopyrazam Difenoconazole Trifloxystrobin 23 MancozebIsopyrazam Epoxiconazole Azoxystrobin 24 Mancozeb IsopyrazamEpoxiconazole Picoxystrobin 25 Mancozeb Isopyrazam EpoxiconazolePyraclostrobin 26 Mancozeb Isopyrazam Epoxiconazole Kresoxim- methyl 27Mancozeb Isopyrazam Epoxiconazole Trifloxystrobin 28 Mancozeb IsopyrazamHexaconazole Azoxystrobin 29 Mancozeb Isopyrazam HexaconazolePicoxystrobin 30 Mancozeb Isopyrazam Hexaconazole Pyraclostrobin 31Mancozeb Isopyrazam Hexaconazole Kresoxim- methyl 32 Mancozeb IsopyrazamHexaconazole Trifloxystrobin 33 Mancozeb Isopyrazam TebuconazoleAzoxystrobin 34 Mancozeb Isopyrazam Tebuconazole Picoxystrobin 35Mancozeb Isopyrazam Tebuconazole Pyraclostrobin 36 Mancozeb IsopyrazamTebuconazole Kresoxim- methyl 37 Mancozeb Isopyrazam TebuconazoleTrifloxystrobin 38 Mancozeb Isopyrazam Tetraconazole Azoxystrobin 39Mancozeb Isopyrazam Tetraconazole Picoxystrobin 40 Mancozeb IsopyrazamTetraconazole Pyraclostrobin 41 Mancozeb Isopyrazam TetraconazoleKresoxim- methyl 42 Mancozeb Isopyrazam Tetraconazole Trifloxystrobin 43Mancozeb Isopyrazam Prothioconazole Azoxystrobin 44 Mancozeb IsopyrazamProthioconazole Picoxystrobin 45 Mancozeb Isopyrazam ProthioconazolePyraclostrobin 46 Mancozeb Isopyrazam Prothioconazole Kresoxim- methyl47 Mancozeb Isopyrazam Prothioconazole Trifloxystrobin

In an embodiment of the combinations of the present invention, thepreferred succinate dehydrogenase inhibitor fungicide isBenzovindiflupyr.

In an embodiment, the combinations of the present invention include thefollowing preferred combinations:

S No. I II III IV 48 Mancozeb Benzovindiflupyr Cyproconazole — 49Mancozeb Benzovindiflupyr Difenoconazole — 50 Mancozeb BenzovindiflupyrEpoxiconazole — 51 Mancozeb Benzovindiflupyr Hexaconazole — 52 MancozebBenzovindiflupyr Tebuconazole — 53 Mancozeb BenzovindiflupyrTetraconazole — 54 Mancozeb Benzovindiflupyr Prothioconazole — 55Mancozeb Benzovindiflupyr — Azoxystrobin 56 Mancozeb Benzovindiflupyr —Picoxystrobin 57 Mancozeb Benzovindiflupyr — Pyraclostrobin 58 MancozebBenzovindiflupyr — Kresoxim- methyl 59 Mancozeb Benzovindiflupyr —Trifloxystrobin 60 Mancozeb Benzovindiflupyr Cyproconazole Azoxystrobin61 Mancozeb Benzovindiflupyr Cyproconazole Picoxystrobin 62 MancozebBenzovindiflupyr Cyproconazole Pyraclostrobin 63 MancozebBenzovindiflupyr Cyproconazole Kresoxim- methyl 64 MancozebBenzovindiflupyr Cyproconazole Trifloxystrobin 65 MancozebBenzovindiflupyr Difenoconazole Azoxystrobin 66 MancozebBenzovindiflupyr Difenoconazole Picoxystrobin 67 MancozebBenzovindiflupyr Difenoconazole Pyraclostrobin 68 MancozebBenzovindiflupyr Difenoconazole Kresoxim- methyl 69 MancozebBenzovindiflupyr Difenoconazole Trifloxystrobin 70 MancozebBenzovindiflupyr Epoxiconazole Azoxystrobin 71 Mancozeb BenzovindiflupyrEpoxiconazole Picoxystrobin 72 Mancozeb Benzovindiflupyr EpoxiconazolePyraclostrobin 73 Mancozeb Benzovindiflupyr Epoxiconazole Kresoxim-methyl 74 Mancozeb Benzovindiflupyr Epoxiconazole Trifloxystrobin 75Mancozeb Benzovindiflupyr Hexaconazole Azoxystrobin 76 MancozebBenzovindiflupyr Hexaconazole Picoxystrobin 77 Mancozeb BenzovindiflupyrHexaconazole Pyraclostrobin 78 Mancozeb Benzovindiflupyr HexaconazoleKresoxim- methyl 79 Mancozeb Benzovindiflupyr HexaconazoleTrifloxystrobin 80 Mancozeb Benzovindiflupyr Tebuconazole Azoxystrobin81 Mancozeb Benzovindiflupyr Tebuconazole Picoxystrobin 82 MancozebBenzovindiflupyr Tebuconazole Pyraclostrobin 83 MancozebBenzovindiflupyr Tebuconazole Kresoxim- methyl 84 MancozebBenzovindiflupyr Tebuconazole Trifloxystrobin 85 MancozebBenzovindiflupyr Tetraconazole Azoxystrobin 86 Mancozeb BenzovindiflupyrTetraconazole Picoxystrobin 87 Mancozeb Benzovindiflupyr TetraconazolePyraclostrobin 88 Mancozeb Benzovindiflupyr Tetraconazole Kresoxim-methyl 89 Mancozeb Benzovindiflupyr Tetraconazole Trifloxystrobin 90Mancozeb Benzovindiflupyr Prothioconazole Azoxystrobin 91 MancozebBenzovindiflupyr Prothioconazole Picoxystrobin 92 MancozebBenzovindiflupyr Prothioconazole Pyraclostrobin 93 MancozebBenzovindiflupyr Prothioconazole Kresoxim- methyl 94 MancozebBenzovindiflupyr Prothioconazole Trifloxystrobin

In an embodiment of the combinations of the present invention, thepreferred succinate dehydrogenase inhibitor fungicide is Penthiopyrad.

In an embodiment, the combinations of the present invention include thefollowing preferred combinations:

S No. I II III IV 95 Mancozeb Penthiopyrad Cyproconazole — 96 MancozebPenthiopyrad Difenoconazole — 97 Mancozeb Penthiopyrad Epoxiconazole —98 Mancozeb Penthiopyrad Hexaconazole — 99 Mancozeb PenthiopyradTebuconazole — 100 Mancozeb Penthiopyrad Tetraconazole — 101 MancozebPenthiopyrad Prothioconazole — 102 Mancozeb Penthiopyrad — Azoxystrobin103 Mancozeb Penthiopyrad — Picoxystrobin 104 Mancozeb Penthiopyrad —Pyraclostrobin 105 Mancozeb Penthiopyrad — Kresoxim- methyl 106 MancozebPenthiopyrad — Trifloxystrobin 107 Mancozeb Penthiopyrad CyproconazoleAzoxystrobin 108 Mancozeb Penthiopyrad Cyproconazole Picoxystrobin 109Mancozeb Penthiopyrad Cyproconazole Pyraclostrobin 110 MancozebPenthiopyrad Cyproconazole Kresoxim- methyl 111 Mancozeb PenthiopyradCyproconazole Trifloxystrobin 112 Mancozeb Penthiopyrad DifenoconazoleAzoxystrobin 113 Mancozeb Penthiopyrad Difenoconazole Picoxystrobin 114Mancozeb Penthiopyrad Difenoconazole Pyraclostrobin 115 MancozebPenthiopyrad Difenoconazole Kresoxim- methyl 116 Mancozeb PenthiopyradDifenoconazole Trifloxystrobin 117 Mancozeb Penthiopyrad EpoxiconazoleAzoxystrobin 118 Mancozeb Penthiopyrad Epoxiconazole Picoxystrobin 119Mancozeb Penthiopyrad Epoxiconazole Pyraclostrobin 120 MancozebPenthiopyrad Epoxiconazole Kresoxim- methyl 121 Mancozeb PenthiopyradEpoxiconazole Trifloxystrobin 122 Mancozeb Penthiopyrad HexaconazoleAzoxystrobin 123 Mancozeb Penthiopyrad Hexaconazole Picoxystrobin 124Mancozeb Penthiopyrad Hexaconazole Pyraclostrobin 125 MancozebPenthiopyrad Hexaconazole Kresoxim- methyl 126 Mancozeb PenthiopyradHexaconazole Trifloxystrobin 127 Mancozeb Penthiopyrad TebuconazoleAzoxystrobin 128 Mancozeb Penthiopyrad Tebuconazole Picoxystrobin 129Mancozeb Penthiopyrad Tebuconazole Pyraclostrobin 130 MancozebPenthiopyrad Tebuconazole Kresoxim- methyl 131 Mancozeb PenthiopyradTebuconazole Trifloxystrobin 132 Mancozeb Penthiopyrad TetraconazoleAzoxystrobin 133 Mancozeb Penthiopyrad Tetraconazole Picoxystrobin 134Mancozeb Penthiopyrad Tetraconazole Pyraclostrobin 135 MancozebPenthiopyrad Tetraconazole Kresoxim- methyl 136 Mancozeb PenthiopyradTetraconazole Trifloxystrobin 137 Mancozeb Penthiopyrad ProthioconazoleAzoxystrobin 138 Mancozeb Penthiopyrad Prothioconazole Picoxystrobin 139Mancozeb Penthiopyrad Prothioconazole Pyraclostrobin 140 MancozebPenthiopyrad Prothioconazole Kresoxim- methyl 141 Mancozeb PenthiopyradProthioconazole Trifloxystrobin

In an embodiment of the combinations of the present invention, thepreferred succinate dehydrogenase inhibitor fungicide is boscalid.

In an embodiment, the combinations of the present invention include thefollowing preferred combinations:

S No. I II III IV 142 Mancozeb Boscalid Cyproconazole — 143 MancozebBoscalid Difenoconazole — 144 Mancozeb Boscalid Epoxiconazole — 145Mancozeb Boscalid Hexaconazole — 146 Mancozeb Boscalid Tebuconazole —147 Mancozeb Boscalid Tetraconazole — 148 Mancozeb BoscalidProthioconazole — 149 Mancozeb Boscalid — Azoxystrobin 150 MancozebBoscalid — Picoxystrobin 151 Mancozeb Boscalid — Pyraclostrobin 152Mancozeb Boscalid — Kresoxim- methyl 153 Mancozeb Boscalid —Trifloxystrobin 154 Mancozeb Boscalid Cyproconazole Azoxystrobin 155Mancozeb Boscalid Cyproconazole Picoxystrobin 156 Mancozeb BoscalidCyproconazole Pyraclostrobin 157 Mancozeb Boscalid CyproconazoleKresoxim- methyl 158 Mancozeb Boscalid Cyproconazole Trifloxystrobin 159Mancozeb Boscalid Difenoconazole Azoxystrobin 160 Mancozeb BoscalidDifenoconazole Picoxystrobin 161 Mancozeb Boscalid DifenoconazolePyraclostrobin 162 Mancozeb Boscalid Difenoconazole Kresoxim- methyl 163Mancozeb Boscalid Difenoconazole Trifloxystrobin 164 Mancozeb BoscalidEpoxiconazole Azoxystrobin 165 Mancozeb Boscalid EpoxiconazolePicoxystrobin 166 Mancozeb Boscalid Epoxiconazole Pyraclostrobin 167Mancozeb Boscalid Epoxiconazole Kresoxim- methyl 168 Mancozeb BoscalidEpoxiconazole Trifloxystrobin 169 Mancozeb Boscalid HexaconazoleAzoxystrobin 170 Mancozeb Boscalid Hexaconazole Picoxystrobin 171Mancozeb Boscalid Hexaconazole Pyraclostrobin 172 Mancozeb BoscalidHexaconazole Kresoxim- methyl 173 Mancozeb Boscalid HexaconazoleTrifloxystrobin 174 Mancozeb Boscalid Tebuconazole Azoxystrobin 175Mancozeb Boscalid Tebuconazole Picoxystrobin 176 Mancozeb BoscalidTebuconazole Pyraclostrobin 177 Mancozeb Boscalid Tebuconazole Kresoxim-methyl 178 Mancozeb Boscalid Tebuconazole Trifloxystrobin 179 MancozebBoscalid Tetraconazole Azoxystrobin 180 Mancozeb Boscalid TetraconazolePicoxystrobin 181 Mancozeb Boscalid Tetraconazole Pyraclostrobin 182Mancozeb Boscalid Tetraconazole Kresoxim- methyl 183 Mancozeb BoscalidTetraconazole Trifloxystrobin 184 Mancozeb Boscalid ProthioconazoleAzoxystrobin 185 Mancozeb Boscalid Prothioconazole Picoxystrobin 186Mancozeb Boscalid Prothioconazole Pyraclostrobin 187 Mancozeb BoscalidProthioconazole Kresoxim- methyl 188 Mancozeb Boscalid ProthioconazoleTrifloxystrobin

In an embodiment of the combinations of the present invention, thepreferred succinate dehydrogenase inhibitor fungicide is IR9792. IR9792is a SDHI fungicide, developed by Isagro, with the proposed common namefluindapyr.

In an embodiment, the combinations of the present invention include thefollowing preferred combinations:

S No. I II III IV 189 Mancozeb IR9792 Cyproconazole — 190 MancozebIR9792 Difenoconazole — 191 Mancozeb IR9792 Epoxiconazole — 192 MancozebIR9792 Hexaconazole — 193 Mancozeb IR9792 Tebuconazole — 194 MancozebIR9792 Tetraconazole — 195 Mancozeb IR9792 Prothioconazole — 196Mancozeb IR9792 — Azoxystrobin 197 Mancozeb IR9792 — Picoxystrobin 198Mancozeb IR9792 — Pyraclostrobin 199 Mancozeb IR9792 — Kresoxim- methyl200 Mancozeb IR9792 — Trifloxystrobin 201 Mancozeb IR9792 CyproconazoleAzoxystrobin 202 Mancozeb IR9792 Cyproconazole Picoxystrobin 203Mancozeb IR9792 Cyproconazole Pyraclostrobin 204 Mancozeb IR9792Cyproconazole Kresoxim- methyl 205 Mancozeb IR9792 CyproconazoleTrifloxystrobin 206 Mancozeb IR9792 Difenoconazole Azoxystrobin 207Mancozeb IR9792 Difenoconazole Picoxystrobin 208 Mancozeb IR9792Difenoconazole Pyraclostrobin 209 Mancozeb IR9792 DifenoconazoleKresoxim- methyl 210 Mancozeb IR9792 Difenoconazole Trifloxystrobin 211Mancozeb IR9792 Epoxiconazole Azoxystrobin 212 Mancozeb IR9792Epoxiconazole Picoxystrobin 213 Mancozeb IR9792 EpoxiconazolePyraclostrobin 214 Mancozeb IR9792 Epoxiconazole Kresoxim- methyl 215Mancozeb IR9792 Epoxiconazole Trifloxystrobin 216 Mancozeb IR9792Hexaconazole Azoxystrobin 217 Mancozeb IR9792 Hexaconazole Picoxystrobin218 Mancozeb IR9792 Hexaconazole Pyraclostrobin 219 Mancozeb IR9792Hexaconazole Kresoxim- methyl 220 Mancozeb IR9792 HexaconazoleTrifloxystrobin 221 Mancozeb IR9792 Tebuconazole Azoxystrobin 222Mancozeb IR9792 Tebuconazole Picoxystrobin 223 Mancozeb IR9792Tebuconazole Pyraclostrobin 224 Mancozeb IR9792 Tebuconazole Kresoxim-methyl 225 Mancozeb IR9792 Tebuconazole Trifloxystrobin 226 MancozebIR9792 Tetraconazole Azoxystrobin 227 Mancozeb IR9792 TetraconazolePicoxystrobin 228 Mancozeb IR9792 Tetraconazole Pyraclostrobin 229Mancozeb IR9792 Tetraconazole Kresoxim- methyl 230 Mancozeb IR9792Tetraconazole Trifloxystrobin 231 Mancozeb IR9792 ProthioconazoleAzoxystrobin 232 Mancozeb IR9792 Prothioconazole Picoxystrobin 233Mancozeb IR9792 Prothioconazole Pyraclostrobin 234 Mancozeb IR9792Prothioconazole Kresoxim- methyl 235 Mancozeb IR9792 ProthioconazoleTrifloxystrobin

In an embodiment of the combinations of the present invention, thepreferred succinate dehydrogenase inhibitor fungicide is Bixafen.

In an embodiment, the combinations of the present invention include thefollowing preferred combinations:

S No. I II III IV 236 Mancozeb Bixafen Cyproconazole — 237 MancozebBixafen Difenoconazole — 238 Mancozeb Bixafen Epoxiconazole — 239Mancozeb Bixafen Hexaconazole — 240 Mancozeb Bixafen Tebuconazole — 241Mancozeb Bixafen Tetraconazole — 242 Mancozeb Bixafen Prothioconazole —243 Mancozeb Bixafen — Azoxystrobin 244 Mancozeb Bixafen — Picoxystrobin245 Mancozeb Bixafen — Pyraclostrobin 246 Mancozeb Bixafen — Kresoxim-methyl 247 Mancozeb Bixafen — Trifloxystrobin 248 Mancozeb BixafenCyproconazole Azoxystrobin 249 Mancozeb Bixafen CyproconazolePicoxystrobin 250 Mancozeb Bixafen Cyproconazole Pyraclostrobin 251Mancozeb Bixafen Cyproconazole Kresoxim- methyl 252 Mancozeb BixafenCyproconazole Trifloxystrobin 253 Mancozeb Bixafen DifenoconazoleAzoxystrobin 254 Mancozeb Bixafen Difenoconazole Picoxystrobin 255Mancozeb Bixafen Difenoconazole Pyraclostrobin 256 Mancozeb BixafenDifenoconazole Kresoxim- methyl 257 Mancozeb Bixafen DifenoconazoleTrifloxystrobin 258 Mancozeb Bixafen Epoxiconazole Azoxystrobin 259Mancozeb Bixafen Epoxiconazole Picoxystrobin 260 Mancozeb BixafenEpoxiconazole Pyraclostrobin 261 Mancozeb Bixafen EpoxiconazoleKresoxim- methyl 262 Mancozeb Bixafen Epoxiconazole Trifloxystrobin 263Mancozeb Bixafen Hexaconazole Azoxystrobin 264 Mancozeb BixafenHexaconazole Picoxystrobin 265 Mancozeb Bixafen HexaconazolePyraclostrobin 266 Mancozeb Bixafen Hexaconazole Kresoxim- methyl 267Mancozeb Bixafen Hexaconazole Trifloxystrobin 268 Mancozeb BixafenTebuconazole Azoxystrobin 269 Mancozeb Bixafen TebuconazolePicoxystrobin 270 Mancozeb Bixafen Tebuconazole Pyraclostrobin 271Mancozeb Bixafen Tebuconazole Kresoxim- methyl 272 Mancozeb BixafenTebuconazole Trifloxystrobin 273 Mancozeb Bixafen TetraconazoleAzoxystrobin 274 Mancozeb Bixafen Tetraconazole Picoxystrobin 275Mancozeb Bixafen Tetraconazole Pyraclostrobin 276 Mancozeb BixafenTetraconazole Kresoxim- methyl 277 Mancozeb Bixafen TetraconazoleTrifloxystrobin 278 Mancozeb Bixafen Prothioconazole Azoxystrobin 279Mancozeb Bixafen Prothioconazole Picoxystrobin 280 Mancozeb BixafenProthioconazole Pyraclostrobin 281 Mancozeb Bixafen ProthioconazoleKresoxim- methyl 282 Mancozeb Bixafen Prothioconazole Trifloxystrobin

In an embodiment of the combinations of the present invention, thepreferred succinate dehydrogenase inhibitor fungicide is Fluxapyroxad.

In an embodiment, the combinations of the present invention include thefollowing preferred combinations:

S No. I II III IV 283 Mancozeb Fluxapyroxad Cyproconazole — 284 MancozebFluxapyroxad Difenoconazole — 285 Mancozeb Fluxapyroxad Epoxiconazole —286 Mancozeb Fluxapyroxad Hexaconazole — 287 Mancozeb FluxapyroxadTebuconazole — 288 Mancozeb Fluxapyroxad Tetraconazole — 289 MancozebFluxapyroxad Prothioconazole — 290 Mancozeb Fluxapyroxad — Azoxystrobin291 Mancozeb Fluxapyroxad — Picoxystrobin 292 Mancozeb Fluxapyroxad —Pyraclostrobin 293 Mancozeb Fluxapyroxad — Kresoxim- methyl 294 MancozebFluxapyroxad — Trifloxystrobin 295 Mancozeb Fluxapyroxad CyproconazoleAzoxystrobin 296 Mancozeb Fluxapyroxad Cyproconazole Picoxystrobin 297Mancozeb Fluxapyroxad Cyproconazole Pyraclostrobin 298 MancozebFluxapyroxad Cyproconazole Kresoxim- methyl 299 Mancozeb FluxapyroxadCyproconazole Trifloxystrobin 300 Mancozeb Fluxapyroxad DifenoconazoleAzoxystrobin 301 Mancozeb Fluxapyroxad Difenoconazole Picoxystrobin 302Mancozeb Fluxapyroxad Difenoconazole Pyraclostrobin 303 MancozebFluxapyroxad Difenoconazole Kresoxim- methyl 304 Mancozeb FluxapyroxadDifenoconazole Trifloxystrobin 305 Mancozeb Fluxapyroxad EpoxiconazoleAzoxystrobin 306 Mancozeb Fluxapyroxad Epoxiconazole Picoxystrobin 307Mancozeb Fluxapyroxad Epoxiconazole Pyraclostrobin 308 MancozebFluxapyroxad Epoxiconazole Kresoxim- methyl 309 Mancozeb FluxapyroxadEpoxiconazole Trifloxystrobin 310 Mancozeb Fluxapyroxad HexaconazoleAzoxystrobin 311 Mancozeb Fluxapyroxad Hexaconazole Picoxystrobin 312Mancozeb Fluxapyroxad Hexaconazole Pyraclostrobin 313 MancozebFluxapyroxad Hexaconazole Kresoxim- methyl 314 Mancozeb FluxapyroxadHexaconazole Trifloxystrobin 315 Mancozeb Fluxapyroxad TebuconazoleAzoxystrobin 316 Mancozeb Fluxapyroxad Tebuconazole Picoxystrobin 317Mancozeb Fluxapyroxad Tebuconazole Pyraclostrobin 318 MancozebFluxapyroxad Tebuconazole Kresoxim- methyl 319 Mancozeb FluxapyroxadTebuconazole Trifloxystrobin 320 Mancozeb Fluxapyroxad TetraconazoleAzoxystrobin 321 Mancozeb Fluxapyroxad Tetraconazole Picoxystrobin 322Mancozeb Fluxapyroxad Tetraconazole Pyraclostrobin 323 MancozebFluxapyroxad Tetraconazole Kresoxim- methyl 324 Mancozeb FluxapyroxadTetraconazole Trifloxystrobin 325 Mancozeb Fluxapyroxad ProthioconazoleAzoxystrobin 326 Mancozeb Fluxapyroxad Prothioconazole Picoxystrobin 327Mancozeb Fluxapyroxad Prothioconazole Pyraclostrobin 328 MancozebFluxapyroxad Prothioconazole Kresoxim- methyl 329 Mancozeb FluxapyroxadProthioconazole Trifloxystrobin

In an embodiment of the combinations of the present invention, thepreferred succinate dehydrogenase inhibitor fungicide is Furametpyr.

In an embodiment, the combinations of the present invention include thefollowing preferred combinations:

S No. I II III IV 330 Mancozeb Furametpyr Cyproconazole — 331 MancozebFurametpyr Difenoconazole — 332 Mancozeb Furametpyr Epoxiconazole — 333Mancozeb Furametpyr Hexaconazole — 334 Mancozeb Furametpyr Tebuconazole— 335 Mancozeb Furametpyr Tetraconazole — 336 Mancozeb FurametpyrProthioconazole — 337 Mancozeb Furametpyr — Azoxystrobin 338 MancozebFurametpyr — Picoxystrobin 339 Mancozeb Furametpyr — Pyraclostrobin 340Mancozeb Furametpyr — Kresoxim- methyl 341 Mancozeb Furametpyr —Trifloxystrobin 342 Mancozeb Furametpyr Cyproconazole Azoxystrobin 343Mancozeb Furametpyr Cyproconazole Picoxystrobin 344 Mancozeb FurametpyrCyproconazole Pyraclostrobin 345 Mancozeb Furametpyr CyproconazoleKresoxim- methyl 346 Mancozeb Furametpyr Cyproconazole Trifloxystrobin347 Mancozeb Furametpyr Difenoconazole Azoxystrobin 348 MancozebFurametpyr Difenoconazole Picoxystrobin 349 Mancozeb FurametpyrDifenoconazole Pyraclostrobin 350 Mancozeb Furametpyr DifenoconazoleKresoxim- methyl 351 Mancozeb Furametpyr Difenoconazole Trifloxystrobin352 Mancozeb Furametpyr Epoxiconazole Azoxystrobin 353 MancozebFurametpyr Epoxiconazole Picoxystrobin 354 Mancozeb FurametpyrEpoxiconazole Pyraclostrobin 355 Mancozeb Furametpyr EpoxiconazoleKresoxim- methyl 356 Mancozeb Furametpyr Epoxiconazole Trifloxystrobin357 Mancozeb Furametpyr Hexaconazole Azoxystrobin 358 MancozebFurametpyr Hexaconazole Picoxystrobin 359 Mancozeb FurametpyrHexaconazole Pyraclostrobin 360 Mancozeb Furametpyr HexaconazoleKresoxim- methyl 361 Mancozeb Furametpyr Hexaconazole Trifloxystrobin362 Mancozeb Furametpyr Tebuconazole Azoxystrobin 363 MancozebFurametpyr Tebuconazole Picoxystrobin 364 Mancozeb FurametpyrTebuconazole Pyraclostrobin 365 Mancozeb Furametpyr TebuconazoleKresoxim- methyl 366 Mancozeb Furametpyr Tebuconazole Trifloxystrobin367 Mancozeb Furametpyr Tetraconazole Azoxystrobin 368 MancozebFurametpyr Tetraconazole Picoxystrobin 369 Mancozeb FurametpyrTetraconazole Pyraclostrobin 370 Mancozeb Furametpyr TetraconazoleKresoxim- methyl 371 Mancozeb Furametpyr Tetraconazole Trifloxystrobin372 Mancozeb Furametpyr Prothioconazole Azoxystrobin 273 MancozebFurametpyr Prothioconazole Picoxystrobin 374 Mancozeb FurametpyrProthioconazole Pyraclostrobin 375 Mancozeb Furametpyr ProthioconazoleKresoxim- methyl 376 Mancozeb Furametpyr Prothioconazole Trifloxystrobin

In an embodiment of the combinations of the present invention, thepreferred succinate dehydrogenase inhibitor fungicide is Penflufen.

In an embodiment, the combinations of the present invention include thefollowing preferred combinations:

S No. I II III IV 377 Mancozeb Penflufen Cyproconazole — 378 MancozebPenflufen Difenoconazole — 379 Mancozeb Penflufen Epoxiconazole — 380Mancozeb Penflufen Hexaconazole — 381 Mancozeb Penflufen Tebuconazole —382 Mancozeb Penflufen Tetraconazole — 383 Mancozeb PenflufenProthioconazole — 384 Mancozeb Penflufen — Azoxystrobin 385 MancozebPenflufen — Picoxystrobin 386 Mancozeb Penflufen — Pyraclostrobin 387Mancozeb Penflufen — Kresoxim- methyl 388 Mancozeb Penflufen —Trifloxystrobin 389 Mancozeb Penflufen Cyproconazole Azoxystrobin 390Mancozeb Penflufen Cyproconazole Picoxystrobin 391 Mancozeb PenflufenCyproconazole Pyraclostrobin 392 Mancozeb Penflufen CyproconazoleKresoxim- methyl 393 Mancozeb Penflufen Cyproconazole Trifloxystrobin394 Mancozeb Penflufen Difenoconazole Azoxystrobin 395 MancozebPenflufen Difenoconazole Picoxystrobin 396 Mancozeb PenflufenDifenoconazole Pyraclostrobin 397 Mancozeb Penflufen DifenoconazoleKresoxim- methyl 398 Mancozeb Penflufen Difenoconazole Trifloxystrobin399 Mancozeb Penflufen Epoxiconazole Azoxystrobin 400 Mancozeb PenflufenEpoxiconazole Picoxystrobin 401 Mancozeb Penflufen EpoxiconazolePyraclostrobin 402 Mancozeb Penflufen Epoxiconazole Kresoxim- methyl 403Mancozeb Penflufen Epoxiconazole Trifloxystrobin 404 Mancozeb PenflufenHexaconazole Azoxystrobin 405 Mancozeb Penflufen HexaconazolePicoxystrobin 406 Mancozeb Penflufen Hexaconazole Pyraclostrobin 407Mancozeb Penflufen Hexaconazole Kresoxim- methyl 408 Mancozeb PenflufenHexaconazole Trifloxystrobin 409 Mancozeb Penflufen TebuconazoleAzoxystrobin 410 Mancozeb Penflufen Tebuconazole Picoxystrobin 411Mancozeb Penflufen Tebuconazole Pyraclostrobin 412 Mancozeb PenflufenTebuconazole Kresoxim- methyl 413 Mancozeb Penflufen TebuconazoleTrifloxystrobin 414 Mancozeb Penflufen Tetraconazole Azoxystrobin 415Mancozeb Penflufen Tetraconazole Picoxystrobin 416 Mancozeb PenflufenTetraconazole Pyraclostrobin 417 Mancozeb Penflufen TetraconazoleKresoxim- methyl 418 Mancozeb Penflufen Tetraconazole Trifloxystrobin419 Mancozeb Penflufen Prothioconazole Azoxystrobin 420 MancozebPenflufen Prothioconazole Picoxystrobin 421 Mancozeb PenflufenProthioconazole Pyraclostrobin 422 Mancozeb Penflufen ProthioconazoleKresoxim- methyl 423 Mancozeb Penflufen Prothioconazole Trifloxystrobin

In an embodiment of the combinations of the present invention, thepreferred succinate dehydrogenase inhibitor fungicide is Sedaxane.

In an embodiment, the combinations of the present invention include thefollowing preferred combinations:

S No. I II III IV 424 Mancozeb Sedaxane Cyproconazole — 425 MancozebSedaxane Difenoconazole — 426 Mancozeb Sedaxane Epoxiconazole — 427Mancozeb Sedaxane Hexaconazole — 428 Mancozeb Sedaxane Tebuconazole —429 Mancozeb Sedaxane Tetraconazole — 430 Mancozeb SedaxaneProthioconazole — 431 Mancozeb Sedaxane — Azoxystrobin 432 MancozebSedaxane — Picoxystrobin 433 Mancozeb Sedaxane — Pyraclostrobin 434Mancozeb Sedaxane — Kresoxim- methyl 435 Mancozeb Sedaxane —Trifloxystrobin 436 Mancozeb Sedaxane Cyproconazole Azoxystrobin 437Mancozeb Sedaxane Cyproconazole Picoxystrobin 438 Mancozeb SedaxaneCyproconazole Pyraclostrobin 439 Mancozeb Sedaxane CyproconazoleKresoxim- methyl 440 Mancozeb Sedaxane Cyproconazole Trifloxystrobin 441Mancozeb Sedaxane Difenoconazole Azoxystrobin 442 Mancozeb SedaxaneDifenoconazole Picoxystrobin 443 Mancozeb Sedaxane DifenoconazolePyraclostrobin 444 Mancozeb Sedaxane Difenoconazole Kresoxim- methyl 445Mancozeb Sedaxane Difenoconazole Trifloxystrobin 446 Mancozeb SedaxaneEpoxiconazole Azoxystrobin 447 Mancozeb Sedaxane EpoxiconazolePicoxystrobin 448 Mancozeb Sedaxane Epoxiconazole Pyraclostrobin 449Mancozeb Sedaxane Epoxiconazole Kresoxim- methyl 450 Mancozeb SedaxaneEpoxiconazole Trifloxystrobin 451 Mancozeb Sedaxane HexaconazoleAzoxystrobin 452 Mancozeb Sedaxane Hexaconazole Picoxystrobin 453Mancozeb Sedaxane Hexaconazole Pyraclostrobin 454 Mancozeb SedaxaneHexaconazole Kresoxim- methyl 455 Mancozeb Sedaxane HexaconazoleTrifloxystrobin 456 Mancozeb Sedaxane Tebuconazole Azoxystrobin 457Mancozeb Sedaxane Tebuconazole Picoxystrobin 458 Mancozeb SedaxaneTebuconazole Pyraclostrobin 459 Mancozeb Sedaxane Tebuconazole Kresoxim-methyl 460 Mancozeb Sedaxane Tebuconazole Trifloxystrobin 461 MancozebSedaxane Tetraconazole Azoxystrobin 462 Mancozeb Sedaxane TetraconazolePicoxystrobin 463 Mancozeb Sedaxane Tetraconazole Pyraclostrobin 464Mancozeb Sedaxane Tetraconazole Kresoxim- methyl 465 Mancozeb SedaxaneTetraconazole Trifloxystrobin 466 Mancozeb Sedaxane ProthioconazoleAzoxystrobin 467 Mancozeb Sedaxane Prothioconazole Picoxystrobin 468Mancozeb Sedaxane Prothioconazole Pyraclostrobin 469 Mancozeb SedaxaneProthioconazole Kresoxim- methyl 470 Mancozeb Sedaxane ProthioconazoleTrifloxystrobin

The combinations of the present invention may be formulated in the formof a composition.

In an embodiment, the present invention may provide a compositioncomprising:

(a) at least one succinate dehydrogenase inhibitor fungicide;

(b) at least one dithiocarbamate fungicide;

(c) at least one quinone outside inhibitor; and

(d) at least one agrochemically acceptable excipient.

In an embodiment, the present invention may provide a compositioncomprising:

(a) at least one succinate dehydrogenase inhibitor fungicide;

(b) at least one dithiocarbamate fungicide;

(c) at least one ergostrol biosynthesis inhibitor; and

(d) at least one agrochemically acceptable excipient.

In an embodiment, the present invention may provide a compositioncomprising:

(a) at least one succinate dehydrogenase inhibitor fungicide;

(b) at least one dithiocarbamate fungicide;

(c) at least one a quinone outside inhibitor;

(d) at least one ergostrol biosynthesis inhibitor; and

(e) at least one agrochemically acceptable excipient.

The amount of a composition according to the invention to be applied,will depend on various factors, such as the subject of the treatment,such as, for example plants, soil or seeds; the type of treatment, suchas, for example spraying, dusting or seed dressing; the purpose of thetreatment, such as, for example prophylactic or therapeutic diseasecontrol; in case of disease control the type of fungi to be controlledor the application time. This amount of the combinations of the presentinvention to be applied can be readily deduced by a skilled agronomist.

Thus in an embodiment, the present invention may provide compositionscomprising:

(a) at least one pyrazaole carboxamide selected from benzovindiflupyr,bixafen, fluxapyroxad, furametpyr, isopyrazam, penflufen, penthiopyrad,and sedaxane;

(b) at least one quinone outside inhibitor, and/or at least oneergostrol biosynthesis inhibitor; and

(c) at last one dithiocarbamate fungicide; said fungicides beingcombined in agrochemically acceptable amounts.

In an embodiment, the total amount of succinate dehydrogenase inhibitorin the composition may typically be in the range of 0.1 to 99% byweight, preferably 0.2 to 90% by weight. The total amount ofdithiocarbamate fungicide in the composition may be in the range of 0.1to 99% by weight. The total amount of ergostrol biosynthesis inhibitorin the composition may be in the range of 0.1 to 99% by weight. Thetotal amount of Quinone outside inhibitor in the composition may be inthe range of 0.1 to 99% by weight.

In an embodiment, the constituent fungicides of the combination of thepresent invention may be admixed in ratio of (1-80): (1-80): (1-80) ofthe dithiocarbamate fungicide, succinate dehydrogenase inhibitorfungicide and the third fungicide respectively.

In an embodiment, the constituents of the composition of the presentinvention may be tank mixed and sprayed at the locus of the infection,or may be alternatively be mixed with surfactants and then sprayed.

In an embodiment, the constituents of the composition of the presentinvention may be used for foliar application, ground or applications toplant propagation materials.

In an embodiment, the compositions of the present invention maytypically be produce by mixing the actives in the composition with aninert carrier, and adding surfactants and other adjuvants and carriersas needed and formulated into solid, or liquid formulations, includingbut not limited to wettable powders, granules, dusts, Soluble (liquid)concentrates, suspension concentrates, oil in water emulsion, water inoil emulsion, emulsifiable concentrates, capsule suspensions, ZCformulations, oil dispersions or other known formulation types. Thecomposition may also be used for treatment of a plant propagationmaterial such as seeds etc.

Examples of the solid carrier used in formulation include fine powdersor granules such as minerals such as kaolin clay, attapulgite clay,bentonite, montmorillonite, acid white clay, pyrophyllite, talc,diatomaceous earth and calcite; natural organic materials such as cornrachis powder and walnut husk powder; synthetic organic materials suchas urea; salts such as calcium carbonate and ammonium sulfate; syntheticinorganic materials such as synthetic hydrated silicon oxide; and as aliquid carrier, aromatic hydrocarbons such as xylene, alkylbenzene andmethylnaphthalene; alcohols such as 2-propanol, ethyleneglycol,propylene glycol, and ethylene glycol monoethyl ether; ketones such asacetone, cyclohexanone and isophorone; vegetable oil such as soybean oiland cotton seed oil; petroleum aliphatic hydrocarbons, esters,dimethylsulfoxide, acetonitrile and water.

Examples of the surfactant include anionic surfactants such as alkylsulfate ester salts, alkylaryl sulfonate salts, dialkyl sulfosuccinatesalts, polyoxyethylene alkylaryl ether phosphate ester salts,lignosulfonate salts and naphthalene sulfonate formaldehydepolycondensates; and nonionic surfactants such as polyoxyethylene alkylaryl ethers, polyoxyethylene alkylpolyoxypropylene block copolymers andsorbitan fatty acid esters and cationic surfactants such asalkyltrimethylammonium salts.

Examples of the other formulation auxiliary agents include water-solublepolymers such as polyvinyl alcohol and polyvinylpyrrolidone,polysaccharides such as Arabic gum, alginic acid and the salt thereof,CMC (carboxymethyl-cellulose), Xanthan gum, inorganic materials such asaluminum magnesium silicate and alumina sol, preservatives, coloringagents and stabilization agents such as PAP (acid phosphate isopropyl)and BHT.

The compositions according to the present invention is effective for thefollowing plant diseases:

-   -   Disease in rice: Blast (Magnaporthe grisea), Helminthosporium        leaf spot (Cochliobolus miyabeanus), sheath blight (Rhizoctonia        solani), and bakanae disease (Gibberella fujikuroi).    -   Diseases in wheat: powdery mildew (Erysiphe graminis), Fusariuin        head blight (Fusarium graminearum, F. avenacerum, F. culmorum,        Microdochium nivale), rust (Puccinia striiformis, P.        graminis, P. recondita), pink snow mold (Micronectriella        nivale), Typhula snow blight (Typhula sp.), loose smut (Ustilago        tritici), bunt (Tilletia caries), eyespot (Pseudocercosporella        herpotrichoides), leaf blotch (Mycosphaerella graminicola),        glume blotch (Stagonospora nodorum), septoria, and yellow spot        (Pyrenophora tritici-repentis)    -   Diseases of barley: powdery mildew (Erysiphe graminis), Fusarium        head blight (Fusarium graminearum, F. avenacerum, F. culmorum,        Microdochium nivale), rust (Puccinia striiformis, P.        graminis, P. hordei), loose smut (Ustilago nuda), scald        (Rhynchosporium secalis), net blotch (Pyrenophora teres), spot        blotch (Cochliobolus sativus), leaf stripe (Pyrenophora        graminea), and Rhizoctonia damping-off (Rhizoctonia solani).    -   Diseases in corn: smut (Ustilago maydis), brown spot        (Cochliobolus heterostrophus), copper spot (Gloeocercospora        sorghi), southern rust (Puccinia polysora), gray leaf spot        (Cercospora zeae-maydis), white spot (Phaeosphaeria mydis and/or        Pantoea ananatis) and Rhizoctonia damping-off (Rhizoctonia        solani).    -   Diseases of citrus: melanose (Diaporthe citri), scab (Elsinoe        fawcetti), penicillium rot (Penicillium digitatum, P. italicum),        and brown rot (Phytophthora parasitica, Phytophthora        citrophthora).    -   Diseases of apple: blossom blight (Monilinia mali), canker        (Valsa ceratosperma), powdery mildew (Podosphaera leucotricha),        Alternaria leaf spot (Alternaria alternata apple pathotype),        scab (Venturia inaequalis), powdery mildew, bitter rot        (Colletotrichum acutatum), crown rot (Phytophtora cactorum),        blotch (Diplocarpon mali), and ring rot (Botryosphaeria        berengeriana).    -   Diseases of pear: scab (Venturia nashicola, V. pirina), powdery        mildew, black spot (Alternaria alternata Japanese pear        pathotype), rust (Gymnosporangium haraeanum), and phytophthora        fruit rot (Phytophtora cactorum).    -   Diseases of peach: brown rot (Monilinia fructicola), powdery        mildew, scab (Cladosporium carpophilum), and phomopsis rot        (Phomopsis sp.).    -   Diseases of grape: anthracnose (Elsinoe ampelina), ripe rot        (Glomerella cingulata), powdery mildew (Uncinula necator), rust        (Phakopsora ampelopsidis), black rot (Guignardia bidwellii),        botrytis, and downy mildew (Plasmopara viticola).    -   Diseases of Japanese persimmon: anthracnose (Gloeosporium kaki),        and leaf spot (Cercospora kaki, Mycosphaerella nawae).    -   Diseases of gourd: anthracnose (Colletotrichum lagenarium),        powdery mildew (Sphaerotheca fuliginea), gummy stem blight        (Mycosphaerella melonis), Fusarium wilt (Fusarium oxysporum),        downy mildew (Pseudoperonospora cubensis), Phytophthora rot        (Phytophthora sp.), and damping-off (Pythium sp.).    -   Diseases of tomato: early blight (Alternaria solani), leaf mold        (Cladosporium fulvum), and late blight (Phytophthora infestans).    -   Diseases of eggplant: brown spot (Phomopsis vexans), and powdery        mildew (Erysiphe cichoracearum)    -   Diseases of cruciferous vegetables: Alternaria leaf spot        (Alternaria japonica), white spot (Cercosporella brassicae),        clubroot (Plasmodiophora brassicae), and downy mildew        (Peronospora parasitica).    -   Diseases of onion: rust (Puccinia allii), and downy mildew        (Peronospora destructor).    -   Diseases of soybean: purple seed stain (Cercospora kikuchii),        sphaceloma scad (Elsinoe glycines), pod and stem blight        (Diaporthe phaseolorum var. sojae), septoria brown spot        (Septoria glycines), frogeye leaf spot (Cercospora sojina), rust        (Phakopsora pachyrhizi), Yellow rust, brown stem rot        (Phytophthora sojae), and Rhizoctonia damping-off (Rhizoctonia        solani).    -   Diseases of kidney bean: anthracnose (Colletotrichum        lindemthianum).    -   Diseases of peanut: leaf spot (Cercospora personata), brown leaf        spot (Cercospora arachidicola) and southern blight (Sclerotium        rolfsii).    -   Diseases of garden pea: powdery mildew (Erysiphe pisi), and root        rot (Fusarium solani f. sp. pisi).    -   Diseases of potato: early blight (Alternaria solani), late        blight (Phytophthora infestans), pink rot (Phytophthora        erythroseptica), and powdery scab (Spongospora subterranean f.        sp. subterranea).    -   Diseases of strawberry: powdery mildew (Sphaerotheca humuli),        and anthracnose (Glomerella cingulata).    -   Diseases of tea: net blister blight (Exobasidium reticulatum),        white scab (Elsinoe leucospila), gray blight (Pestalotiopsis        sp.), and anthracnose (Colletotrichum theae-sinensis).    -   Diseases of tobacco: brown spot (Alternaria longipes), powdery        mildew (Erysiphe cichoracearum), anthracnose (Colletotrichum        tabacum), downy mildew (Peronospora tabacina), and black shank        (Phytophthora nicotianae).    -   Diseases of rapeseed: sclerotinia rot (Sclerotinia        sclerotiorum), and Rhizoctonia damping-off (Rhizoctonia solani).    -   Diseases of cotton: Rhizoctonia damping-off (Rhizoctonia        solani).    -   Diseases of sugar beat: Cercospora leaf spot (Cercospora        beticola), leaf blight (Thanatephorus cucumeris), Root rot        (Thanatephorus cucumeris), and Aphanomyces root rot (Aphanomyces        cochlioides).    -   Diseases of rose: black spot (Diplocarpon rosae), powdery mildew        (Sphaerotheca pannosa), and downy mildew (Peronospora sparsa).    -   Diseases of chrysanthemum and asteraceous plants: downy mildew        (Bremia lactucae), leaf blight (Septoria chrysanthemi-indici),        and white rust (Puccinia horiana).    -   Diseases of various groups: diseases caused by Pythium spp.        (Pythium aphanidermatum, Pythium debarianum, Pythium        graminicola, Pythium irregulare, Pythium ultimum), gray mold.        (Botrytis cinerea), and Sclerotinia rot (Sclerotinia        sclerotiorum).    -   Disease of Japanese radish: Alternaria leaf spot (Alternaria        brassicicola).    -   Diseases of turfgrass: dollar spot (Sclerotinia homeocarpa), and        brown patch and large patch (Rhizoctonia solani).    -   Disease of banana: Black sigatoka (Mycosphaerella fijiensis),        Yellow sigatoka (Mycosphaerella musicola).    -   Disease of sunflower: downy mildew (Plasmopara halstedii).    -   Seed diseases or diseases in the early stages of the growth of        various plants caused by Aspergillus spp., Penicillium spp.,        Fusarium spp., Gibberella spp., Tricoderma spp., Thielaviopsis        spp., Rhizopus spp., Mucor spp., Corticium spp., Phoma spp.,        Rhizoctonia spp. and Diplodia spp.    -   Viral diseases of various plants mediated by Polymixa spp. or        Olpidium spp. and so on.

The compositions of the present invention can be used in agriculturallands such as fields, paddy fields, lawns and orchards or innon-agricultural lands. The present invention may be used to controldiseases in agricultural lands for cultivating the plants without anyphytotoxicity to the plant.

Examples of the crops on which the present compositions may be usedinclude but are not limited to corn, rice, wheat, barley, rye, oat,sorghum, cotton, soybean, peanut, buckwheat, beet, rapeseed, sunflower,sugar cane, tobacco, etc.; vegetables: solanaceous vegetables such aseggplant, tomato, pimento, pepper, potato, etc., cucurbit vegetablessuch as cucumber, pumpkin, zucchini, water melon, melon, squash, etc.,cruciferous vegetables such as radish, white turnip, horseradish,kohlrabi, Chinese cabbage, cabbage, leaf mustard, broccoli, cauliflower,etc., asteraceous vegetables such as burdock, crown daisy, artichoke,lettuce, etc, liliaceous vegetables such as green onion, onion, garlic,and asparagus, ammiaceous vegetables such as carrot, parsley, celery,parsnip, etc., chenopodiaceous vegetables such as spinach, Swiss chard,etc., lamiaceous vegetables such as Perilla frutescens, mint, basil,etc, strawberry, sweet potato, Dioscorea japonica, colocasia, etc.,flowers, foliage plants, turf grasses, fruits: pome fruits such apple,pear, quince, etc, stone fleshy fruits such as peach, plum, nectarine,Prunus mume, cherry fruit, apricot, prune, etc., citrus fruits such asorange, lemon, rime, grapefruit, etc., nuts such as chestnuts, walnuts,hazelnuts, almond, pistachio, cashew nuts, macadamia nuts, etc. berriessuch as blueberry, cranberry, blackberry, raspberry, etc., grape, kakifruit, olive, plum, banana, coffee, date palm, coconuts, etc., treesother than fruit trees; tea, mulberry, flowering plant, trees such asash, birch, dogwood, Eucalyptus, Ginkgo biloba, lilac, maple, Quercus,poplar, Judas tree, Liquidambar formosana, plane tree, zelkova, Japanesearborvitae, fir wood, hemlock, juniper, Pinus, Picea, and Taxuscuspidate, etc.

In an embodiment, the constituent fungicides of the combination of thepresent invention may be admixed in ratio of (1-80): (1-80): (1-80):(1:80)

In an aspect, the present invention may provide methods of controllingfungal diseases comprising applying a combination comprising:

(a) at least one succinate dehydrogenase inhibitor fungicide;

(b) at least one quinone outside inhibitor and/or at least one ergostrolbiosynthesis inhibitor; and

(c) at least one dithiocarbamate fungicide.

In an embodiment, the succinate dehydrogenase inhibitor fungicide, thequinone outside inhibitor fungicide, the ergosterol biosynthesisinhibitor fungicide, and the dithiocarbamate fungicide may be selectedaccording to any of the preferred embodiments of the combinationsdescribed hereinabove.

The combinations of the present invention may be sold as a pre-mixcomposition or a kit of parts such that individual actives may be mixedbefore spraying. Alternatively, the kit of parts may contain succinatedehydrogenase inhibitor fungicide and the dithiocarbamate fungicidepre-mixed and the third active may be admixed with an adjuvant such thatthe two components may be tank mixed before spraying.

The composition of the present invention may be applied simultaneouslyas a tank mix or a formulation or may be applied sequentially. Theapplication may be made to the soil before emergence of the plants,either pre-planting or post-planting. The application may be made as afoliar spray at different timings during crop development, with eitherone or two applications early or late post-emergence.

The compositions according to the invention can be applied before orafter infection of the useful plants or the propagation material thereofby the fungi.

As will be demonstrated in the examples, the addition of adithiocarbamate fungicide to a combination of succinate dehydrogenaseinhibitors which are combined with Quinone outside inhibitors and/orergosterol biosynthesis inhibitors, greatly improved the disease controlas well as improved yield and demonstrated a synergistic effect. Thelower the mixture performance in the disease control, the greater theadditional benefit of the mancozeb when added to the compositions of thepresent invention.

Examples: Studies were conducted to study the addition ofdithiocarbamate fungicides to succinate dehydrogenase inhibitorfungicides and at least one other fungicide and the contribution of thedithiocarbamate to the efficacy of these mixtures. Experiments wereconducted over a period of two years to study the effect of the additionof dithiocarbamates on the efficacy of succinate dehydrogenaseinhibitors alone and when combined with a co-fungicide such as a Quinoneoutside inhibitors and/or ergosterol biosynthesis inhibitor fungicide.Doses tested were at rates of 1500 g/ha for Mancozeb, 150 ml/ha for theergosterol biosynthesis inhibitor, 200 g/ha for the Quinone outsideinhibitor, 1000 g/ha and 200 g/ha for succinate dehydrogenase inhibitorfungicides. The combinatios were tested for efficacy of disease controlin soybean for the control of Asian soybean rust. The trials werecarried out at various locations in India.

The tests were conducted on soybean cultivar Monsoy 9144 RR. Thecommercially available individual active ingredients were used at theindicated dosages.

TABLE 1 Table 1 shows the efficacy of mancozeb when added tocombinations containing succinate dehydrogenase inhibitor fungicides andergosterol biosynthesis inhibitor. Mean percent disease controlTreatment Dose rates (ml/g/ha) 2015/16 2016/17 Prothioconazole + 150 +200 88.04 71.04 Benzovindiflupyr Prothioconazole + 150 + 200 + 150095.07 95.07 Benzovindiflupyr + Mancozeb Prothioconazole + Isopyrazam150 + 1000 87.14 70.23 Prothioconazole + Isopyrazam + 150 + 1000 + 150093.4 93.07 Mancozeb Prothioconazole + Penthoipyrad 150 + 1000 83.3368.15 Prothioconazole + 150 + 1000 + 1500 93.07 92.18 Penthiopyrad +Mancozeb Table 1 clearly demonstrates the increase in control whenmancozeb is added to the combination of ergosterol biosynthesisinhibitors and succinate dehydrogenase inhibitor fungicides.

TABLE 2 Table 2 demonstrates effiacacy when mancozeb is added tocombinations of succinate dehydrogenase inhibitor fungicides and quinoneoutside inhibitor fungicides and ergosterol biosynthesis inhibitors.Mean percent disease control Treatment Dose rates (ml/g/ha) 2015/162016/17 Prothioconazole + 150 + 200 + 500 93.07 91.07 Benzovindiflupyr +Azoxystrobin Prothioconazole + 150 + 200 + 500 + 1500 96.36 95.03Benzovindiflupyr + Azoxystrobin + Mancozeb Table 2 clearly demonstratesthe importance of adding mancozeb to the combination. The addition ofmancozeb improved disease control.

It was thus found that the incorporation of mancozeb greatly increasedefficacy and disease control of the succinate dehydrogenase inhibitorfungicide treatments when mixed with ergosterol biosynthesis inhibitorsor quinone outside inhibitors. It was thus concluded that the additionof mancozeb enhanced the efficacy of the combination and surprisinglygave a synergistic effect. The addition of a dithiocarbamate increaseddisease control and improved yield of plants. The instant invention ismore specifically explained by above examples. However, it should beunderstood that the scope of the present invention is not limited by theexamples in any manner. It will be appreciated by any person skilled inthis art that the present invention includes aforesaid examples andfurther can be modified and altered within the technical scope of thepresent invention.

While the foregoing written description of the invention enables one ofordinary skill to make and use what is considered presently to be thebest mode thereof, those of ordinary skill will understand andappreciate the existence of variations, combinations, and equivalents ofthe specific embodiment, method, and examples herein. The inventionshould therefore not be limited by the above described embodiment,method, and examples, but by all embodiments and methods within thescope and spirit of the invention.

1. A fungicidal combination comprising at least one succinatedehydrogenase inhibitor fungicide, a dithiocarbamate fungicideconsisting of mancozeb, and at least one additional fungicide, whereinsuccinate dehydrogenase inhibitor fungicide is selected from the groupconsisting of fluxapyroxad, and fluindapyr.
 2. The fungicidalcombination as claimed in claim 1, wherein the at least additionalfungicide is selected from the group consisting of an ergosterolbiosynthesis inhibitor fungicide, a quinone outside inhibitor fungicide,and combinations thereof.
 3. The fungicidal combination as claimed inclaim 2, wherein the ergosterol biosynthesis inhibitors is selectedazaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole,diniconazole, epoxiconazole, etaconazole, fenbuconazole,fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole,Ipconazole, metconazole, myclobutanil, penconazole, Propiconazole,simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol,triticonazole, prothioconazole, imazalil, oxpoconazole, pefurazoate,prochloraz, triflumizole, fenarimol, nuarimol, pyrifenox, pyrisoxazole,triforine and mixtures thereof.
 4. The fungicidal combination as claimedin claim 3, wherein the quinone outside (Qo) inhibitor fungicide isselected from azoxystrobin, coumoxystrobin, enoxastrobin,flufenoxystrobin, picoxystrobin, pyraoxystrobin, mandestrobin,pyraclostrobin, pyrametostrobin, triclopyricarb, kresoxim-methyl,dimoxystrobin, fenaminostrobin, metominostrobin, trifloxystrobin,famoxadone, fluoxastrobin, fenamidone, pyribencarb and mixtures thereof.5. The fungicidal combination as claimed in claim 1, further comprisingat least two additional fungicides.
 6. The fungicidal combination asclaimed in claim 1, consisting of: (a) the mancozeb; (b) the succinatedehydrogenase inhibitor fungicide; and (c) cyproconazole,difenoconazole, epoxiconazole, hexaconazole, hexaconazole, tebuconazole,tetraconazole, prothioconazole, azoxystrobin, picoxystrobin,pyraclostrobin, kresoxim-methyl, trifloxystrobin, and combinationsthereof.
 7. The fungicidal combination as claimed in claim 1, consistingof: (a) the mancozeb; and (b) the succinate dehydrogenase inhibitorfungicide; and (c) prothioconazole and/or azoxystrobin.
 8. Thefungicidal combination as claimed in claim 1, consisting of: a) themancozeb; and b) the succinate dehydrogenase inhibitor fungicide; and c)prothioconazole and/or tebuconazole.
 9. The fungicidal composition ofclaim 1, further comprising at least one agrochemically acceptableexcipient.
 10. The fungicidal combination as claimed in claim 9, whereinthe combination comprises wettable powders, granules, dusts, soluble(liquid) concentrates, suspension concentrates, oil in water emulsion,water in oil emulsion, emulsifiable concentrates, capsule suspensions,ZC formulations, or oil dispersions.
 11. The fungicidal combination asclaimed in claim 1, wherein the constituent fungicides of thecombination are admixed in ratio of (1-80): (1-80): (1-80).
 12. Thefungicidal combination as claimed in claim 2, wherein the succinatedehydrogenase inhibitor is in a range of 0.1 to 99% by weight, themancozeb is in a range of 0.1 to 99% by weight; the ergostrolbiosynthesis inhibitor n is in a range of 0.1 to 99% by weight; and thetotal amount of quinone outside inhibitor is in a range of 0.1 to 99% byweight based on total weight of the combination.
 13. The fungicidalcomposition of claim 1, wherein the composition is used for foliarapplication, or applications to plant propagation materials.
 14. Amethod of controlling fungal diseases comprising applying to the locusof the plant the combination as claimed in claim 1.